AlivaMab Mouse Platform

Engineered by Design for Success

The AlivaMab Mouse platform improves upon other transgenic animal antibody discovery platforms by incorporating insights and scientific breakthroughs based on:

  • Ablexis founders' decades of experience in designing, engineering and utilizing earlier-generation antibody discovery platforms
  • New understandings of the function of the immune system
  • The sequences of the human and mouse genomes

AlivaMab Mouse immunoglobulin (Ig) loci are specifically designed for optimal function to help meet the challenges of both antibody drug discovery and antibody drug development. Innovative technologies were used to create the specialized transgene designs for the AlivaMab immunoglobulin loci, improving upon the limited bacterial artificial chromosome (BAC) and yeast artificial chromosome (YAC) genomic library approaches of other technologies.

The AlivaMab Mouse supports the efficient discovery and development of the next wave of human therapeutic antibodies to treat disease. Validated features of the platform include:

  • Broad diversity of human variable repertoires to recognize a wide array of epitopes and target classes
  • Immune responses that naturally generate potent and target-specific antibodies
  • AlivaMab antibodies supporting efficient discovery and development of high-quality therapeutics
  • Freedom to operate